SCIENTIFIC PROGRAMME

4th ITALIAN ZEBRAFISH MEETING

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7 February 2024

12.00 - REGISTRATION

13.30 - OPENING

14.00 - 15.00 - KEYNOTE LECTURE: From fish embryos to human patients: lymphangiogenesis in zebrafish and beyond. Stefan Schulte-Merker - University

of Munster

Chair: Marina Mione (UniTN)

DEVELOPMENT AND DIFFERENTIATION

Chairs: Massimiliano Andreazzoli (UniPI) and Filippo del Bene (INSERM)

15.00 - 15.15 - Sox1 genes contribute to unveiling the neural diversity in the ventral spinal cord of zebrafish. Sepand Rastegar (KIT)

15.15 - 15.30 - Knock-out of setd5 maternal mRNA leads to abnormal zebrafish brain development and ASD-like behavioural features. Matteo Di Gregorio (UniPI)

15.30 - 15.45 - Exploring the role of Zebrafish Impg2a and Impg2b in Retinal Development and Disease. Luigi Balasco (UniTN)

15.45 -16.00 - NRP1 acts as a mediator of SEMA3A chemorepulsive cues to guide vessel sprouting. Marco Spreafico (UniMI)

16.00 - 16.15 - The Wnt inhibitory factor 1: a case of genetic adaptation? . Samuele Sartori (UniTN)

16.15 - 16.45 - Coffee break

CANCER

Chairs: Anna Pistocchi (UniMI) and Massimo Santoro (UniPD)

16.45 - 17.00 - 3D culture transplantation in zebrafish embryos: an innovative approach to study in vivo tumor dynamics. Giacomo Miserocchi (UniBS)

17.00 - 17.15 - LTD4-dependent activation of YAP signaling in uveal melanoma supports tumor progression. Francesca Lorenzini (UniTN)

17.15 - 17.30 - Hedgehog and HDAC6 in cancers: dissection of dysregulated biological mechanisms and potential therapeutic treatments. Alex Pezzotta (UniMI)

17.30 - 17.45 - Lactate reshapes myelofibrosis tumor microenvironment. Sebastiano Giallongo (UniCT)

17.45 - 18.00 - Poster Preview 1

18.00 - 19.00 - Poster Session

8 February 2024

09.00 - 10.00 - KEYNOTE LECTURE: From development to therapeutic mRNAs:

Combining genomics and expansion microscopy to understand the basic mechanisms of transcription and translation. Antonio Giraldez - Yale School of Medicine

Chair: Vincenzo Cavalieri (UniPA)

EMERGING TECHNOLOGIES

Chairs: Simona Casarosa (UniTN) and Alessandro Cellerino (SNS)

10.00 - 10.15 - Fast, efficient and flexible manipulation of neuronal activity with single cell precision. Filippo Del Bene (INSERM)

10.15 - 10.30 - High density electrophysiological recordings in zebrafish larvae across multiple brain regions. Marta D'Amora (IIT)

10.30 - 11.00 - Coffee break

DISCOVERY, TOXICOLOGY AND STRESS

Chairs: Michela Ori (UniPI) and Tiziano Verri (UniSALENTO)

11.00 - 11.15 - High throughput in vivo screening of compounds to find novel factors affecting the zebrafish habenular circuit development and linking it to neuropsychiatric disorders. Judith Habicher (UniTN)

11.15 - 11.30 - Exploring the protective effects of secretome from Wharton's jelly mesenchymal stem cells in zebrafish. Vincenzo Cavalieri (UniPA)

11.30 - 11.45 - Insights on the role of lysosomal protein cln5 in neurodegeneration using zebrafish as a tool. Maria Marchese (ISM)

11.45 - 12.00 - Characterization of a zebrafish model for SPG4 Hereditary Spastic Paraplegia and in vivo drug screening. Francesca Greco (UniVR)

12.00 - 12.15 - Dietary Probiotic reduces BPA waterborne toxicity: zebrafish as valuable model for translational research. Francesca Maradonna (UnivPM)

12.15 - 12.30 - Evaluation of stress response in adult zebrafish (Danio rerio)

exposed to intermittent fasting. Elisa Fonsatti (UniPD)

12.30 -12.45 - Group Photo

12.45 -14.00 - Lunch

DISEASES MODELS 1

Chairs: Dario Finazzi (UNIBS) and Natascia Tiso (UniPD)

14.00 - 14.15 - ADA2 regulates inflammation and hematopoietic stem cells emergence via the A2bR pathway in zebrafish. Alessia Brix (UniMI)

14.15 - 14.30 - Increased levels of beta-glucosyl-sitosterol trigger intestinal dysfunction: gut-brain axis could pave the way for neurodegeneration. Francesca Terrin (UniPD)

14.30 - 14.45 - Hdac1 regulates cardiomyocyte proliferation during development and heart regeneration. Anja Buhler (UniULM)

14.45 - 15.00 - Modeling Sarcoglycanopathy in Zebrafish: generation of valuable tools for enhanced disease understanding and drug screening. Francesco Dalla Barba (UniPD)

15.00 - 15.15 - Uncovering early signs preceding disease-onset in a zebrafish model of rare tubulinopathy exhibiting untreatable neurodegeneration. Antonella Lauri (OPBG)

15.15 - 15.45 - Coffee Break

DISEASES MODELS II

Chairs: Livia D'Angelo (UniNA) and Daniele Tibullo (UniCT)

15.45 - 16.00 - Zebrafish for modeling Alexander disease. Deianira Bellitto (UniGE)

16.00 - 16.15 - The role of PS727 Stat3 regulation of Vitamin D pathway in the pathogenesis of Job's syndrome. Annachiara Tesoriere (UniPD)

16.15 - 16.30 - Modeling rare neurodevelopmental disorders: Pitt Hopkins syndrome and de novo pathogenetic variants of TCF4 gene. Michela Ori (UniPI)

16.30 - 16.45 - Assessment of Teen sensor fish to detect early RASopathy-associated ERK activation and its pharmacological modulation. Giulia Fasano (OPGB)

16.45 - 17.00 - A novel model for Krabbe disease in zebrafish. Luca Mignani (UniBS)

17.00 - 17.15 - Sponsor Talk: Tritone XS, big advantages in a small solution!. Tommaso Sala (Tecniplast)

17.15 - 17.30 - Poster Preview 2

17.30 - 18.45 - Poster Session

19.00 - Guided tour in historical city center

21.00 - Social dinner

9 February 2024

09.00 - 10.00 - KEYNOTE LECTURE: Sleep facilitates neuronal maintenance across evolution. Lior Appelbaum - Bar Ilan University

Chair: Francesco Argenton (UniPD)

NUTRITION

Chairs: Paolo Sordino (SZN) and Fabio Marino (UniME)

10.00 - 10.15 - Zebrafish feed intake: a systematic review for standardizing feeding management in laboratory conditions. Rosario Licitra (ISM)

10.15 - 10.30 - Differential Impact of Rosemary and Lemon Extracts on the Intestinal Microbiome of Zebrafish Larvae. Marzio Cometa (UniME)

10.30 - 11.00 - Coffee Break

11.00 - 11.10 - Sponsor talk: Standard and custom made behavioural tracking solutions for zebrafish. Guillaume Lopez (Viewpoint)

11.10 - 11.15 - Sponsor talk: EggSorter: THE device to automate zebrafish egg sorting. Cristina Anghel Mills (Bionomous)

NEUROBIOLOGY AND BEHAVIOUR

Chairs: Cristiano Bertolucci (UniFE) and Chiara Gabellini (UniPI)

11.15 - 11.30 - Zebrafish as a model for biodiversity threats: impacts of light pollution on behaviour and cognition. Gaia De Russi (UniFE)

11.30 - 11.45 - Serotoninergic regulation of body axis alignment in the post embryonic zebrafish. Giulia Messa (ICM)

11.45 - 12.00 - Neural plasticity genes’ expression and knockout zebrafish reveal the basis of individual differences in cognition. Elia Gatto (UniFE)

12.00 - 12.15 - Study of neurodegeneration and nuclear morphological changes in the fast-aging teleost Nothobranchius furzeri. Sara Bagnoli

(SNS)

12.15 - 12.30 - A neural path for visual discrimination of magnitudes in zebrafish. Andrea Messina (UniTN)

13.00 - IZM Awards assignment

13.15 - Election of the next meeting site

13.30 - Closing remarks

List of
affiliations

WWW MUNSTER - University of Munster
UniTN - University of Trento
UniPI - University of Pisa
INSERM - Institut national de la santé et de la recherche médicale
KIT - Karlsruhe Institute of Technology
UniMI - University of Milan
UniPD - University of Padua
UniBS - University of Brescia
UniCT - University of Catania
UniPA - University of Palermo
SNS - Scuola Normale Superiore
IIT - Italian Institute of Technology
UniSALENTO - University of Salento
ISM - IRCCS STELLA MARIS
UniVR - University of Verona
UnivPM - Polytechnic University of Marche
UniULM - Ulm University
SNZ - Stazione Zoologica Anton Dohrn
OPBG - Ospedale Pediatrico Bambin Gesù
UniNA - University of Naples
UniGE - University of Genoa
UniME - University of Messina
UniFE - University of Ferrara